601 264 6000
South Mississippi's Largest Multi-Specialty Clinic

Hattiesburg Clinic



Owl Drug Store has been Hattiesburg’s hometown pharmacy for over 100 years.

In 1907, the pharmacy opened at the corner of Main and Front Street in downtown Hattiesburg. There, Owl Drug Store was established as Hattiesburg’s original family pharmacy.

In 1985, we moved from our downtown location to Hattiesburg Clinic’s main facility on 28th Avenue. As a part of Hattiesburg Clinic, we were able to continue our legacy as a neighborhood pharmacy, with a more convenient location.

At Owl Drug Store, we strive to meet your pharmacy needs through friendly, fast service. Our pharmacists, Debra V. Akers, RPh; Mike Easterling, RPh; and Laura G. Lofton, PharmD, are available for prescription discussion.

As a commitment to our customers, we continue to keep up with the technological advances in the pharmacy industry. We offer many features that allow you more convenient access to pharmacy services:

  • Free delivery to nearby locations*.
  • Email and text notifications when prescriptions are ready.
  • Online refill requests.
  • Drive-thru.

*Please ask an associate about our delivery radius.


Owl Drug Store gladly accepts Mississippi Medicaid and MississippiCAN health plans, including Magnolia, Molina, and UHC Community Plan. We also welcome TRICARE and Blue Cross Blue Shield, as well as most insurances and Medicare Part D plans.


In order to transfer your prescription to Owl Drug Store, please call (601) 268-5740. Provide the receptionist with your patient information, the prescription number and the name/number of current pharmacy. We will take care of making sure all loose ends are tied and fill your prescription. Please note, state law prohibits the transfer of controlled medications.


Debra V. Akers, RPh
Mike Easterling, RPh
Laura G. Lofton, PharmD


Main Clinic – 1st Floor
#2 Medical Blvd.
Hattiesburg, MS 39401

*If you call after hours, please leave a message with our call system and your call will be returned when the pharmacy opens.

Fa La La Fridays

Owl Drug Store is prescribing you savings this holiday season with “Fa La La Fridays!”

Stroll into the pharmacy each Friday, beginning Nov. 30 through Dec. 21, for a special deal on select merchandise.

Mark your calendar for the following savings:

  • Friday, Nov. 30 – All holiday and home decor and toys 25% off; all fall decor 50% off. Excludes clothing and jewelry.
  • Friday, Dec. 7 – Clothing and fashion accessories 25% off. Includes jewelry, handbags, scarves, tote and rolling bags, umbrellas, gloves, ear muffs, socks, hats, and toboggans; all baby items 25% off.
  • Friday, Dec. 14 – All books 25% off. Choice Books included.
  • Friday, Dec. 21 – 35% off store-wide. Excludes all food and drink; regular and sale price Choice Books; all over-the-counter medications and health and beauty/personal care and wound care items.
  • Every Friday (except Dec. 21) – 10% off Leader® brand over-the-counter cough and cold medicines.

The following items are excluded during Fa La La Fridays, due to other specials throughout the month: Kringle® Candles, Couture Tee Company, Flathau’s Cookies and Big Little Fudge®. Regular priced Choice Books will be excluded, except on Dec. 21. All greeting cards are excluded as well. Please also note discounts do not include prescription medications.

You’ll also get one free gift wrap when you purchase $25 in retail merchandise (does not include prescription purchases). Purchases less than $25 can be gift wrapped for $3 per package.

Let Owl Drug Store serve as your one-stop shop for all your pharmacy and holiday gift needs!

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Please do not use this contact form to send any messages requiring urgent attention. For urgent medical matters, contact your doctor’s office or visit the nearest emergency room. This messaging system is monitored only during normal business hours. It is not monitored after hours or on holidays.

Prescription Ready Alerts:

Text and email alerts notify you when your prescription is ready. To sign up for these alerts, speak with an Owl Drug Store associate at your next visit – or fill out the form below:

Your Full Name

Your Email

Phone #

Use RefillRx mobile app to manage your prescriptions!