601 264 6000
South Mississippi's Largest Multi-Specialty Clinic

Hattiesburg Clinic


Owl Drug Store has been Hattiesburg’s hometown pharmacy for over 100 years.

In 1907, the pharmacy opened at the corner of Main and Front Street in downtown Hattiesburg. There, Owl Drug Store was established as Hattiesburg’s original family pharmacy.

In 1985, we moved from our downtown location to Hattiesburg Clinic’s main facility on 28th Avenue. As a part of Hattiesburg Clinic, we were able to continue our legacy as a neighborhood pharmacy, with a more convenient location.

At Owl Drug Store, we strive to meet your pharmacy needs through friendly, fast service. Our pharmacists, Debra V. Akers, RPh; Mike Easterling, RPh; and Laura G. Lofton, PharmD, are available for prescription discussion.

Owl Drug Store Staff Photo 2018

As a commitment to our customers, we continue to keep up with the technological advances in the pharmacy industry. We offer many features that allow you more convenient access to pharmacy services:

  • Free delivery to nearby locations*.
  • Email and text notifications when prescriptions are ready.
  • Online refill requests.
  • Drive-thru.

*Please ask an associate about our delivery radius.


Owl Drug Store proudly accepts Magnolia Health, United Health Community Plan, Molina Healthcare, Medicaid, all Medicare D plans, Tricare and most major insurances.

Transfer your Prescription!

In order to transfer your prescription to Owl Drug Store, please call 601-268-5740. Provide the receptionist with your patient information, the prescription number and the name/number of current pharmacy. We will take care of making sure all loose ends are tied and fill your prescription. Please note, state law prohibits the transfer of controlled medications.


Debra V. Akers, RPh
Mike Easterling, RPh
Laura G. Lofton, PharmD


Main Clinic – 1st Floor
#2 Medical Blvd.
Hattiesburg, MS 39401
Get directions!

If you call after hours, please leave a message with our call system and your call will be returned when the pharmacy opens.

Low Cost Prescriptions

Click here for the Low Cost Prescription List

Prescription Ready Alerts:

Text and email alerts notify you when your prescription is ready. To sign up for these alerts, speak with an Owl Drug Store associate at your next visit – or fill out the form below:

Your Full Name

Your Email

Phone #

Refill your Prescription!

We know you are busy, and it’s important to us that we offer all of our customers an easier way to refill prescriptions! Through RefillRx Mobile, you don’t have to call and recite the prescription number – your smart phone does all of the work.

To use the application, enter the prescription number. RefillRX will send the request to Owl Drug Store. After the request is received, you can pick up your prescription within an hour.