601 264 6000
South Mississippi's Largest Multi-Specialty Clinic

Hattiesburg Clinic



Owl Drug Store has been Hattiesburg’s hometown pharmacy for over 100 years.

In 1907, the pharmacy opened at the corner of Main and Front Street in downtown Hattiesburg. There, Owl Drug Store was established as Hattiesburg’s original family pharmacy.

In 1985, we moved from our downtown location to Hattiesburg Clinic’s main facility on 28th Avenue. As a part of Hattiesburg Clinic, we were able to continue our legacy as a neighborhood pharmacy, with a more convenient location.

At Owl Drug Store, we strive to meet your pharmacy needs through friendly, fast service. Our pharmacists, Debra V. Akers, RPh; Mike Easterling, RPh; and Laura G. Lofton, PharmD, are available for prescription discussion.

As a commitment to our customers, we continue to keep up with the technological advances in the pharmacy industry. We offer many features that allow you more convenient access to pharmacy services:

  • Free delivery to nearby locations*.
  • Email and text notifications when prescriptions are ready.
  • Online refill requests.
  • Drive-thru.

*Please ask an associate about our delivery radius.


Owl Drug Store gladly accepts Mississippi Medicaid and MississippiCAN health plans, including Magnolia, Molina, and UHC Community Plan. We also welcome TRICARE and Blue Cross Blue Shield, as well as most insurances and Medicare Part D plans.


In order to transfer your prescription to Owl Drug Store, please call (601) 268-5740. Provide the receptionist with your patient information, the prescription number and the name/number of current pharmacy. We will take care of making sure all loose ends are tied and fill your prescription. Please note, state law prohibits the transfer of controlled medications.


Debra V. Akers, RPh
Mike Easterling, RPh
Laura G. Lofton, PharmD


Main Clinic – 1st Floor
#2 Medical Blvd.
Hattiesburg, MS 39401

*If you call after hours, please leave a message with our call system and your call will be returned when the pharmacy opens.

Ask a Question:

    Your Full Name:

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    Please do not use this contact form to send any messages requiring urgent attention. For urgent medical matters, contact your doctor’s office or visit the nearest emergency room. This messaging system is monitored only during normal business hours. It is not monitored after hours or on holidays.

    Prescription Ready Alerts:

    Text and email alerts notify you when your prescription is ready. To sign up for these alerts, speak with an Owl Drug Store associate at your next visit – or fill out the form below:

      Your Full Name

      Your Email

      Phone #

      Using RefillQuick™ is simple:

      Step 1: Download the app from the App Store for your iPhone or Android.

      Step 2: Search and add Owl Drug Store as your pharmacy of choice.

      Step 3: Enter your prescription number or scan it with your phone’s camera.

      Step 4: Select which Delivery Method you want.

      Step 5: Continue and click “Send Request.”