Cognito HOPE Study

Help advance a new way of treating Alzheimer’s disease.

HOPE Study Overview

The Cognito HOPE Study for Alzheimer’s disease is investigating a non-invasive wearable study device with the potential to slow the progression of mild to moderate Alzheimer’s.

While many investigational drug treatments directly target widely known amyloid plaques and tau tangles in the brain, this device targets other contributing factors to Alzheimer’s, such as the abnormal electrical activities in the brain. This approach represents an opportunity to treat Alzheimer’s with a new modality and could bring a much-needed treatment option to many impacted by this devastating disease.

There are no medications involved in this study. The investigational medical device consists of headphones and eyewear and delivers treatment through sensory stimulation in the comfort of patients’ homes.

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    About Alzheimer’s Disease

    Alzheimer’s is a type of brain disorder that causes problems with memory, thinking and behavior. It is a gradually progressive condition with no current cure. Alzheimer’s currently affects more than 5 million people in the United States and is under-recognized as the sixth leading cause of death in our country. Although Alzheimer’s is the most common form of dementia in ages 65 and older, younger people are being diagnosed with increased frequency.

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    What does the HOPE Study involve?

    If you are eligible and choose to enroll in the HOPE Study, you will:

    • Use a non-invasive wearable study device at home on a daily basis for approximately 12 months
    • Participate in study-related visits at clinical sites with experienced health care professionals in the presence of a study partner, such as a family member or friend
    • Receive compensation for study-related expenses (such as travel) and time, for both the participant and study partner

    No drugs or highly invasive procedures are involved in the HOPE study. Additionally, no insurance or out-of-pocket expenses are necessary.

    Why participate in the HOPE Study?

    By joining the HOPE Study, you will help advance a new way of treating Alzheimer’s. You or your loved one may have access to a novel investigational treatment which may slow the progression of mild to moderate Alzheimer’s.

    Who is eligible to participate?

    You or a loved one may be eligible to join the study if you/they are:

    • Between 50 and 90 years of age
    • Have been diagnosed with Alzheimer’s disease by a health care professional
    • Have a reliable study partner, such as a family member or friend, who can help with participation in the study
    • Meet other criteria which will be evaluated

    Additional Criteria:

    • Must not have profound hearing loss
    • Must not have taken Memantine within the past 30 days
    • Must not live in a continuous care nursing facility
    To find out if you or a loved one may be eligible to participate, contact Hattiesburg Clinic Memory Center.

    (601) 268-5620

    Study Results

    In a 6-month long phase-2 study, treatment delivered through this investigational device has shown to significantly slow the progression of Alzheimer’s through preservation of cognitive and daily function, as well as whole brain volume among treated participants.

    Patients across multiple clinical studies have completed over 40,000 treatment sessions to date and tolerated the study device well. No treatment limiting serious adverse events were reported.

    How do I join?

    Talk to your doctor about whether the HOPE Study is a good fit for you or your loved one.

    For more information, call Hattiesburg Clinic Memory Center at (601) 268-5620.
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